High sensitivity bio-luminescence, fluorescence and/or Cerenkov imaging of samples with an ultra-cooled CCD camera designed for optimal detection of low intensity light. The IVIS Spectrum allows for spectral scanning from blue to near-infrared (NIR) wavelengths by using 10 narrow band excitation filters (30nm bandwidth) and 18 narrow band emission filters (20nm bandwidth).
The spectral unmixing tool enables separation of multiple fluorescent reporters within the same sample. High throughput imaging (5 units) is possible with the 23cm FOV, and high resolution (20µm) with the 3.9cm FOV.

Major applications of optical imaging include monitoring of disease progression (eg primary tumour growth and metastatic spread), tracking of adoptively transferred immune cells, and bio-distribution of fluorescently-labelled nanoparticles.